Publications

2025

A composite symptoms severity score based on survey self-reports as a predictor of SARS-CoV-2 infection and viral load
A composite symptoms severity score based on survey self-reports as a predictor of SARS-CoV-2 infection and viral load
Diaz D, Canchola JA, Groh AM, Toptan T, Jarem D, Kuchta AL, Moonsamy P, Berger A, Vehreschild MJGT, Ciesek S
BMC infectious diseases  ·  23 Sep 2025  ·  pmid-40988039
Temporal Dynamics of SARS-CoV-2 Detection in Household Contacts: Divergences Between Time to First Positive Test, Symptom Onset, and Maximum Viral Load
Temporal Dynamics of SARS-CoV-2 Detection in Household Contacts: Divergences Between Time to First Positive Test, Symptom Onset, and Maximum Viral Load
Berger A, Groh AM, Diaz D, Canchola JA, Toptan T, Ciesek S, Jarem D, Kuchta AL, Moonsamy P, Vehreschild MJGT
Infectious diseases and therapy  ·  01 Nov 2025  ·  pmid-40986174

2024

Kinetics of SARS-CoV-2 infection biomarkers in a household transmission study
Kinetics of SARS-CoV-2 infection biomarkers in a household transmission study
Groh AM, Vehreschild MJGT, Diaz D, Kuchta AL, Dodoo C, …, Robbins EM, Moonsamy P, Toptan T, Ciesek S, Berger A
Scientific reports  ·  29 May 2024  ·  pmid-38811590

2023

Pathogenetic mechanisms and therapeutic approaches of acute-to-chronic liver failure
Pathogenetic mechanisms and therapeutic approaches of acute-to-chronic liver failure
Schierwagen R, Gu W, Brieger A, Brüne B, Ciesek S, …, ACLF-I Investigators, , Schaefer L, Welsch C, Trebicka J
American journal of physiology. Cell physiology  ·  01 Jul 2023  ·  pmid-37273239
Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform
Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform
Bojkova D, Reus P, Panosch L, Bechtel M, Rothenburger T, …, Stack R, Ciesek S, Wass MN, Michaelis M, Cinatl J Jr
iScience  ·  17 Feb 2023  ·  pmid-36644320
Comparison of the Ct-values for genomic and subgenomic SARS-CoV-2 RNA reveals limited predictive value for the presence of replication competent virus
Comparison of the Ct-values for genomic and subgenomic SARS-CoV-2 RNA reveals limited predictive value for the presence of replication competent virus
Roesmann F, Jakobsche I, Pallas C, Wilhelm A, Raffel J, …, Toptan T, Berger A, Goetsch U, Ciesek S, Widera M
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology  ·  01 Aug 2023  ·  pmid-37327554
Machine learning on large scale perturbation screens for SARS-CoV-2 host factors identifies β-catenin CBP inhibitor PRI-724 as a potent antiviral
Machine learning on large scale perturbation screens for SARS-CoV-2 host factors identifies β-catenin/CBP inhibitor PRI-724 as a potent antiviral
Kelch MA, Vera-Guapi A, Beder T, Oswald M, Hiemisch A, …, Wajda P, Ciesek S, Erfle H, Toptan T, Koenig R
Frontiers in microbiology  ·  01 Jan 2023  ·  pmid-37342561

2022

The Relapse Phenomenon in Mild COVID Treated With Nirmatrelvir Ritonavir in an Immunocompetent Patient
The Relapse Phenomenon in Mild COVID Treated With Nirmatrelvir/Ritonavir in an Immunocompetent Patient
Hoehl S, Toptan T, Rabenau HF, Ciesek S
Deutsches Arzteblatt international  ·  16 Sep 2022  ·  pmid-36507731
Molecular Analyses of Clinical Isolates and Recombinant SARS-CoV-2 Carrying B.1 and B.1.617.2 Spike Mutations Suggest a Potential Role of Non-Spike Mutations in Infection Kinetics
Molecular Analyses of Clinical Isolates and Recombinant SARS-CoV-2 Carrying B.1 and B.1.617.2 Spike Mutations Suggest a Potential Role of Non-Spike Mutations in Infection Kinetics
Veleanu A, Kelch MA, Ye C, Flohr M, Wilhelm A, Widera M, Martinez-Sobrido L, Ciesek S, Toptan T
Viruses  ·  12 Sep 2022  ·  pmid-36146823
Limited neutralisation of the SARS-CoV-2 Omicron subvariants BA.1 and BA.2 by convalescent and vaccine serum and monoclonal antibodies
Limited neutralisation of the SARS-CoV-2 Omicron subvariants BA.1 and BA.2 by convalescent and vaccine serum and monoclonal antibodies
Wilhelm A, Widera M, Grikscheit K, Toptan T, Schenk B, …, Herrmann E, Helfritz FA, Wolf T, Goetsch U, Ciesek S
EBioMedicine  ·  01 Aug 2022  ·  pmid-35834885
Low But Recoverable Markers of Humoral Immune Response to BNT162b2 in Elderly LTCF Residents Five to Seven Months After Two-Dose Vaccination
Low But Recoverable Markers of Humoral Immune Response to BNT162b2 in Elderly LTCF Residents Five to Seven Months After Two-Dose Vaccination
Delbrück M, Hoehl S, Toptan T, Schenk B, Grikscheit K, Metzler M, Herrmann E, Ciesek S
Frontiers in aging  ·  01 Jan 2022  ·  pmid-35821813

2021

The Comparative Clinical Performance of Four SARS-CoV-2 Rapid Antigen Tests and Their Correlation to Infectivity In Vitro
The Comparative Clinical Performance of Four SARS-CoV-2 Rapid Antigen Tests and Their Correlation to Infectivity In Vitro
Kohmer N, Toptan T, Pallas C, Karaca O, Pfeiffer A, …, Berger A, Hoehl S, Kammel M, Ciesek S, Rabenau HF
Journal of clinical medicine  ·  17 Jan 2021  ·  pmid-33477365
Evaluation of a SARS-CoV-2 rapid antigen test: Potential to help reduce community spread
Evaluation of a SARS-CoV-2 rapid antigen test: Potential to help reduce community spread?
Toptan T, Eckermann L, Pfeiffer AE, Hoehl S, Ciesek S, Drosten C, Corman VM
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology  ·  01 Feb 2021  ·  pmid-33352470
Antibody-Mediated Neutralization of Authentic SARS-CoV-2 B.1.617 Variants Harboring L452R and T478K E484Q
Antibody-Mediated Neutralization of Authentic SARS-CoV-2 B.1.617 Variants Harboring L452R and T478K/E484Q
Wilhelm A, Toptan T, Pallas C, Wolf T, Goetsch U, Gottschalk R, Vehreschild MJGT, Ciesek S, Widera M
Viruses  ·  26 Aug 2021  ·  pmid-34578275
High-Frequency Self-Testing by Schoolteachers for Sars-Cov-2 Using a Rapid Antigen Test Results of the Safe School Hesse study
High-Frequency Self-Testing by Schoolteachers for Sars-Cov-2 Using a Rapid Antigen Test–Results of the Safe School Hesse study
Hoehl S, Schenk B, Rudych O, Göttig S, Foppa I, Kohmer N, Karaca O, Toptan T, Ciesek S
Deutsches Arzteblatt international  ·  09 Apr 2021  ·  pmid-34114556
Surveillance of SARS-CoV-2 in Frankfurt am Main from October to December 2020 Reveals High Viral Diversity Including Spike Mutation N501Y in B.1.1.70 and B.1.1.7
Surveillance of SARS-CoV-2 in Frankfurt am Main from October to December 2020 Reveals High Viral Diversity Including Spike Mutation N501Y in B.1.1.70 and B.1.1.7
Widera M, Mühlemann B, Corman VM, Toptan T, Beheim-Schwarzbach J, …, Tesch J, Gottschalk R, Jones TC, Ciesek S, Drosten C
Microorganisms  ·  02 Apr 2021  ·  pmid-33918332
Generation of a Sleeping Beauty Transposon-Based Cellular System for Rapid and Sensitive Screening for Compounds and Cellular Factors Limiting SARS-CoV-2 Replication
Generation of a Sleeping Beauty Transposon-Based Cellular System for Rapid and Sensitive Screening for Compounds and Cellular Factors Limiting SARS-CoV-2 Replication
Widera M, Wilhelm A, Toptan T, Raffel JM, Kowarz E, …, Reis J, Bracharz S, Pallas C, Ciesek S, Marschalek R
Frontiers in microbiology  ·  01 Jan 2021  ·  pmid-34394046
Pediatrics and COVID-19
Pediatrics and COVID-19
Toptan T, Ciesek S, Hoehl S
Advances in experimental medicine and biology  ·  01 Jan 2021  ·  pmid-33973180

2020

Proteomic approach to discover human cancer viruses from formalin-fixed tissues
Proteomic approach to discover human cancer viruses from formalin-fixed tissues
Toptan T, Cantrell PS, Zeng X, Liu Y, Sun M, Yates NA, Chang Y, Moore PS
JCI insight  ·  19 Nov 2020  ·  pmid-33055416
Optimized qRT-PCR Approach for the Detection of Intra- and Extra-Cellular SARS-CoV-2 RNAs
Optimized qRT-PCR Approach for the Detection of Intra- and Extra-Cellular SARS-CoV-2 RNAs
Toptan T, Hoehl S, Westhaus S, Bojkova D, Berger A, Rotter B, Hoffmeier K, Cinatl J Jr, Ciesek S, Widera M
International journal of molecular sciences  ·  20 Jun 2020  ·  pmid-32575728
Kaposi s Sarcoma-Associated Herpesvirus-Encoded circRNAs Are Expressed in Infected Tumor Tissues and Are Incorporated into Virions
Kaposi's Sarcoma-Associated Herpesvirus-Encoded circRNAs Are Expressed in Infected Tumor Tissues and Are Incorporated into Virions
Abere B, Li J, Zhou H, Toptan T, Moore PS, Chang Y
mBio  ·  07 Jan 2020  ·  pmid-31911496
Merkel Cell Polyomavirus Encodes Circular RNAs circRNAs Enabling a Dynamic circRNA microRNA mRNA Regulatory Network
Merkel Cell Polyomavirus Encodes Circular RNAs (circRNAs) Enabling a Dynamic circRNA/microRNA/mRNA Regulatory Network
Abere B, Zhou H, Li J, Cao S, Toptan T, Grundhoff A, Fischer N, Moore PS, Chang Y
mBio  ·  15 Dec 2020  ·  pmid-33323517

2019

Widespread keratosis pilaris-like eruption in an immunocompromised child
Widespread keratosis pilaris-like eruption in an immunocompromised child
Frigerio A, Toptan T, Chang Y, Abbott J, Cipriano SD, Bowen AR
JAAD case reports  ·  01 Apr 2019  ·  pmid-31008165

2018

Circular DNA tumor viruses make circular RNAs
Circular DNA tumor viruses make circular RNAs
Toptan T, Abere B, Nalesnik MA, Swerdlow SH, Ranganathan S, Lee N, Shair KH, Moore PS, Chang Y
Proceedings of the National Academy of Sciences of the United States of America  ·  11 Sep 2018  ·  pmid-30150410
Treatment of human polyomavirus-7-associated rash and pruritus with topical cidofovir in a lung transplant patient: Case report and literature review
Treatment of human polyomavirus-7-associated rash and pruritus with topical cidofovir in a lung transplant patient: Case report and literature review
Smith SDB, Erdag G, Cuda JD, Rangwala S, Girardi N, Bibee K, Orens JB, Prono MD, Toptan T, Loss MJ
Transplant infectious disease : an official journal of the Transplantation Society  ·  01 Feb 2018  ·  pmid-29064138
Limited detection of human polyomaviruses in Fanconi anemia related squamous cell carcinoma
Limited detection of human polyomaviruses in Fanconi anemia related squamous cell carcinoma
Toptan T, Brusadelli MG, Turpin B, Witte DP, Surrallés J, …, Dietrich R, Brakenhoff RH, Moore PS, Chang Y, Wells SI
PloS one  ·  01 Jan 2018  ·  pmid-30589865
Characterization of a Merkel Cell Polyomavirus-Positive Merkel Cell Carcinoma Cell Line CVG-1
Characterization of a Merkel Cell Polyomavirus-Positive Merkel Cell Carcinoma Cell Line CVG-1
Velásquez C, Amako Y, Harold A, Toptan T, Chang Y, Shuda M
Frontiers in microbiology  ·  01 Jan 2018  ·  pmid-29696010

2016

Identification and Characterization of Novel Rat Polyomavirus 2 in a Colony of X-SCID Rats by P-PIT assay
Identification and Characterization of Novel Rat Polyomavirus 2 in a Colony of X-SCID Rats by P-PIT assay
Rigatti LH, Toptan T, Newsome JT, Moore PS, Chang Y
mSphere  ·  01 Nov 2016  ·  pmid-28028546
Survey for human polyomaviruses in cancer
Survey for human polyomaviruses in cancer
Toptan T, Yousem SA, Ho J, Matsushima Y, Stabile LP, Fernández-Figueras MT, Bhargava R, Ryo A, Moore PS, Chang Y
JCI insight  ·  01 Feb 2016  ·  pmid-27034991

2015

Merkel cell polyomavirus T antigens promote cell proliferation and inflammatory cytokine gene expression
Merkel cell polyomavirus T antigens promote cell proliferation and inflammatory cytokine gene expression
Richards KF, Guastafierro A, Shuda M, Toptan T, Moore PS, Chang Y
The Journal of general virology  ·  01 Dec 2015  ·  pmid-26385761

2014

Human DNA tumor viruses generate alternative reading frame proteins through repeat sequence recoding
Human DNA tumor viruses generate alternative reading frame proteins through repeat sequence recoding
Kwun HJ, Toptan T, Ramos da Silva S, Atkins JF, Moore PS, Chang Y
Proceedings of the National Academy of Sciences of the United States of America  ·  14 Oct 2014  ·  pmid-25271323

2013

2012

Survivin is a therapeutic target in Merkel cell carcinoma
Survivin is a therapeutic target in Merkel cell carcinoma
Arora R, Shuda M, Guastafierro A, Feng H, Toptan T, …, Vogt A, Dömling A, Brodsky JL, Chang Y, Moore PS
Science translational medicine  ·  09 May 2012  ·  pmid-22572880

2011

Merkel cell polyomavirus large T antigen disrupts lysosome clustering by translocating human Vam6p from the cytoplasm to the nucleus
Merkel cell polyomavirus large T antigen disrupts lysosome clustering by translocating human Vam6p from the cytoplasm to the nucleus
Liu X, Hein J, Richardson SC, Basse PH, Toptan T, Moore PS, Gjoerup OV, Chang Y
The Journal of biological chemistry  ·  13 May 2011  ·  pmid-21454559

2010

Rhadinovirus vector-derived human telomerase reverse transcriptase expression in primary T cells
Rhadinovirus vector-derived human telomerase reverse transcriptase expression in primary T cells
Toptan T, Ensser A, Fickenscher H
Gene therapy  ·  01 May 2010  ·  pmid-20164858